Vitamin D, tryptophan and omega-3 to boost brain serotonin during pregnancy and beyond
Vitamin D activates the enzyme TPH2 (tryptophan hydroxylase 2) that converts tryptophan to serotonin – the calming neurotransmitter in the brain. Vitamin D inhibits TPH1, which reduces serotonin in the gut and elsewhere, thus reducing inflammation.
The study’s authors propose that in addition to vitamin D, mothers and children should take extra tryptophan and omega-3 fatty acids to boost brain serotonin. I couldn’t agree more. In pregnancy you should absolutely take 5000 IU’s of vitamin D daily along with your prenatal vitamins and omega-3 supplements, and with this study’s information, I would add tryptophan to that list.
Below is the abstract which is technical and detailed, but best read as written:
“Serotonin and vitamin D have been proposed to play a role in autism; however, no causal mechanism has been established. Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE. The proposed mechanism explains 4 major characteristics associated with autism: the low concentrations of serotonin in the brain and its elevated concentrations in tissues outside the blood-brain barrier; the low concentrations of the vitamin D hormone precursor 25-hydroxyvitamin D [25(OH)D3]; the high male prevalence of autism; and the presence of maternal antibodies against fetal brain tissue. Two peptide hormones, oxytocin and vasopressin, are also associated with autism and genes encoding the oxytocin-neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor contain VDREs for activation. Supplementation with vitamin D and tryptophan is a practical and affordable solution to help prevent autism and possibly ameliorate some symptoms of the disorder.”
Support Dr. Paul:
TAKE ADVANTAGE OF DR PAUL'S 25% PROFESSIONAL DISCOUNT APPLIED AT CHECKOUT
Dr. Paul's Safe and Effective Approach to Immunity and Health- from Pregnancy Through Your Child's Teen Years.
The Vaccine-Friendly Plan is a place to start researching your decision on whether or not to vaccinate according to the CDC recommendations.
Dr. Paul's book, The Vaccine-Friendly Plan, may not align with his latest findings on the Vaxxed-Unvaxxed data. However, it still serves as a valuable tool for those who follow the CDC schedule. The book offers peer-reviewed information encouraging parents and guardians to think critically about vaccine decisions. While Dr. Paul cautions against following the Vaccine-Friendly Plan, it can still be a helpful resource for those seeking a starting point for their vaccine journey.
Dr. Paul's research: https://www.mdpi.com/1660-4601/17/22/8674/pdf, though wrongfully retracted as shown in this study: Revisiting Excess Diagnoses of Illnesses and Conditions in Children Whose Parents Provided Informed Permission to Vaccinate clearly shows that those children who were not vaccinated were much healthier than those who followed the Vaccine-Friendly Plan.
Opiate addiction is the single most significant public health crisis facing Americans—it affects over 2 million people and kills 115 of them every day.
- To the point
Dr. Paul Thomas
Dr. Paul Thomas is an award-winning Dartmouth-trained pediatrician with nearly 30 years of experience in pediatrics. He is an expert on addiction and in Addiction Medicine. He is the co-author of the forthcoming book, The Vaccine-Friendly Plan: Dr. Paul’s Safe and Effective Approach to Immunity and Health—from Pregnancy through Your Child’s Teen Years (Ballantine 2016).
2022 Fall-Winter Newsletter
Autism And Autoimmune Disorders
COVID CON & Beyond
Dr Paul Approved
Dr. Paul Thomas
Health Freedom South Dakota H.O.L.D.
HEALTH FREEDOM SUMMIT 2023
OmegaGenics SPM Active
Pure Body Extra
The Addiction Spectrum
The Truth About Vaccines: REMEDY
Vaccine Friendly Plan